Panax Notoginseng Saponins Enhances the Cytotoxicity of Cisplatin <i>via</i> Increasing Gap Junction Intercellular Communication
نویسندگان
چکیده
منابع مشابه
Determination of Panax notoginseng Saponins
The feasible, reliable and selective multi-template molecularly imprinted polymers (MT17 MIPs) based on SBA-15 (SBA-15@MT-MIPs) for the selective separation and determination of the 18 trace level of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1) and notoginsenoside R1 (R1) (Panax 19 notoginseng saponins, PNS) from biological samples were developed. The polymers were 20 constructed by SBA-15 as s...
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Oxaliplatin is widely used in the treatment of variety of cancers, including cancer of the testis and colorectum. Gap junctions (GJs) can amplify the cytotoxicity of antinoeoplastic drugs through the bystander effect in different cancer cells. In this study, we demonstrate that total flavonoids of litsea coreana (TFLC), one extract from the dried leaves of litsea coreana leve, increase the cyto...
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The goal of this experiment was to investigate the protective effect and the molecular mechanism of Panax Notoginseng Saponins (PNS) on cisplatin-induced nephrotoxicity through mitochondrial pathway of apoptosis. The rats underwent intraperitoneal injection with a single dose of cisplatin, a subset of rats were also intraperitoneally injected with 31.35 mg/kg PNS once a day for 8 days. At day 1...
متن کاملDammarane-type triterpene saponins from the flowers of Panax notoginseng.
Four new dammarane-type triterpene saponins named floranotoginsenosides A (1), B (2), C (3) and D (4), together with five known triterpene saponins, were isolated from the flowers of Panax notoginseng. Their structures were elucidated on the basis of spectral and chemical evidence.
متن کاملAssembly of gap junction intercellular communication channels.
788 with a lipidlprotein molar ratio of 100:1, a value close to that found in most biological membranes [21]. The data show that the calculation of distances between sites within the monomer of a membrane protein of a cross-sectional diameter of 5 nm based only from FET efficiency measurements is largely speculative in most cases in native biological membranes. Because the contribution of FET t...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2012
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b110535